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Symbol
Name
ID

Reln
reelin
MGI:103022

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Primary microcephaly

Dysphagia

Cerebral calcification

Hypoplasia of the pons

Lissencephaly

4-layered lissencephaly

Microlissencephaly

Thick cerebral cortex

Agenesis of corpus callosum

Hypoplasia of the corpus callosum

Cerebellar hypoplasia

Cerebellar atrophy

Abnormality of neuronal migration

EEG abnormality

Abnormal nonverbal communicative behavior

Delayed speech and language development

Lack of spontaneous play

Impaired ability to form peer relationships

Autism

Inflexible adherence to routines

Motor stereotypy

Restrictive behavior

Intellectual disability

Global developmental delay

Profound global developmental delay

Severe global developmental delay

Seizure

Focal sensory seizure with auditory features

Generalized-onset seizure

Disease(s) Associated with RELN

autistic disorder

familial temporal lobe epilepsy 7

Norman-Roberts syndrome

Mouse Phenotypes

nervous system phenotype

abnormal neuron differentiation

abnormal axon extension

abnormal neuronal migration

abnormal cortical marginal zone morphology

abnormal cerebellum development

absent cerebellar foliation

abnormal cerebellum external granule cell layer morphology

abnormal rostral migratory stream morphology

abnormal ventral striatum morphology

abnormal entorhinal cortex morphology

abnormal hippocampus morphology

abnormal hippocampus CA1 region morphology

abnormal hippocampus CA2 region morphology

abnormal dentate gyrus morphology

abnormal hippocampus layer morphology

abnormal hippocampus granule cell layer

abnormal hippocampus pyramidal cell layer

abnormal cerebral cortex morphology

abnormal stratification in cerebral cortex

abnormal olfactory bulb morphology

abnormal olfactory bulb granule cell layer morphology

abnormal olfactory cortex morphology

abnormal cerebellum morphology

abnormal cerebellar cortex morphology

abnormal cerebellar Purkinje cell layer

abnormal Purkinje cell morphology

Purkinje cell degeneration

decreased Purkinje cell number

ectopic Purkinje cell

delaminated Purkinje cell layer

abnormal cerebellar granule layer morphology

delaminated cerebellar granule layer

small cerebellum

abnormal postnatal subventricular zone morphology

abnormal sensory neuron innervation pattern

decreased dopaminergic neuron number

abnormal retina rod bipolar cell morphology

abnormal prepulse inhibition

Availability

Mouse Genotype

Reln^rl-2J/Reln^rl-2J

Reln^rl-4J/Reln^rl-4J

Reln^rl-5J/Reln^rl-5J

Reln^rl-6J/Reln^rl-6J

Reln^rl-7J/Reln^rl-7J

Reln^rl-8J/Reln^rl-8J

Reln^rl-Alb/Reln^rl-Alb

Reln^rl-od/Reln^rl-od

Reln^rl-Orl/Reln^rl-Orl

Reln^rl-tg/Reln^rl-tg

Reln^rl/Reln^rl

Reln^rl/Reln^rl
Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw

Reln^tm1.1Mhat/Reln^tm1.1Mhat

*

Reln^rl/Reln⁺

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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